MESTINON vs NEOSTIGMINE METHYLSULFATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. MESTINON and NEOSTIGMINE METHYLSULFATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MESTINON	NEOSTIGMINE METHYLSULFATE
Rating	New	70/100
Pharmacy pays	$0.60 /mL	—
Type	RX	RX
Active ingredient	PYRIDOSTIGMINE BROMIDE	NEOSTIGMINE METHYLSULFATE
Manufacturer	Bausch	Meitheal
Dosage forms	Solution, Tablet, Tablet, extended release	Injectable
Drug class	Cholinesterase Inhibitor	Cholinesterase Inhibitor
Boxed warning	None	None
Treats	Drug-Induced Abnormalities, Myasthenia Gravis	Drug-Induced Abnormalities, Urinary Bladder Diseases, Myasthenia Gravis

mestinon neostigmine methylsulfate

Rating

New

70/100

Pharmacy pays

$0.60 /mL

—

Type

Active ingredient

PYRIDOSTIGMINE BROMIDE

NEOSTIGMINE METHYLSULFATE

Manufacturer

Bausch

Meitheal

Dosage forms

Solution, Tablet, Tablet, extended release

Injectable

Drug class

Cholinesterase Inhibitor

Boxed warning

None

Treats

Drug-Induced Abnormalities, Myasthenia Gravis

Drug-Induced Abnormalities, Urinary Bladder Diseases, Myasthenia Gravis

Frequently asked questions

What is the difference between Mestinon and Neostigmine Methylsulfate?

Mestinon contains Pyridostigmine Bromide, while Neostigmine Methylsulfate contains Neostigmine Methylsulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.