MELLARIL-S vs TRILAFON

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. MELLARIL-S and TRILAFON are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MELLARIL-S	TRILAFON
Rating	70/100	New
Pharmacy pays	~$22.23 /30	~$5.68 /30
Type	RX	RX
Active ingredient	THIORIDAZINE	PERPHENAZINE
Manufacturer	Novartis	Schering
Dosage forms	Suspension	Tablet
Drug class	Phenothiazine	Phenothiazine
Boxed warning	None	None
Treats	Psychotic Disorders, Schizophrenia	Tourette Syndrome, Huntington Disease, Nausea

mellaril-s trilafon

Rating

70/100

New

Pharmacy pays

~$22.23 /30

~$5.68 /30

Type

Active ingredient

THIORIDAZINE

PERPHENAZINE

Manufacturer

Novartis

Schering

Dosage forms

Suspension

Tablet

Drug class

Phenothiazine

Boxed warning

None

Treats

Psychotic Disorders, Schizophrenia

Tourette Syndrome, Huntington Disease, Nausea

Frequently asked questions

Which is cheaper, Mellaril-S or Trilafon?

Trilafon costs pharmacies less to acquire — about $5.68 vs $22.23 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mellaril-S and Trilafon?

Mellaril-S contains Thioridazine, while Trilafon contains Perphenazine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.