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MELLARIL-S vs PROMETHAZINE PLAIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. MELLARIL-S and PROMETHAZINE PLAIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

~$22.23 /30
~$1.53 /30

Type

RX
RX

Active ingredient

THIORIDAZINE
PROMETHAZINE HYDROCHLORIDE

Dosage forms

Suspension
Syrup

Drug class

Phenothiazine
Phenothiazine

Boxed warning

Half-life

about 9 to 16 hours

Treats

Psychotic Disorders, Schizophrenia
Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

Frequently asked questions

Which is cheaper, Mellaril-S or Promethazine Plain?

Promethazine Plain costs pharmacies less to acquire — about $1.53 vs $22.23 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mellaril-S and Promethazine Plain?

Mellaril-S contains Thioridazine, while Promethazine Plain contains Promethazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.