MELLARIL-S vs PROCHLORPERAZINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. MELLARIL-S and PROCHLORPERAZINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MELLARIL-S	PROCHLORPERAZINE
Rating	70/100	70/100
Pharmacy pays	~$22.23 /30	~$5.22 /30
Type	RX	RX
Active ingredient	THIORIDAZINE	PROCHLORPERAZINE MALEATE
Manufacturer	Novartis	Watson Labs
Dosage forms	Suspension	Suppository, Tablet
Drug class	Phenothiazine	Phenothiazine
Boxed warning	None	None
Treats	Psychotic Disorders, Schizophrenia	Anxiety Disorders, Dementia, Nausea

mellaril-s prochlorperazine

Rating

70/100

Pharmacy pays

~$22.23 /30

~$5.22 /30

Type

Active ingredient

THIORIDAZINE

PROCHLORPERAZINE MALEATE

Manufacturer

Novartis

Watson Labs

Dosage forms

Suspension

Suppository, Tablet

Drug class

Phenothiazine

Boxed warning

None

Treats

Psychotic Disorders, Schizophrenia

Anxiety Disorders, Dementia, Nausea

Frequently asked questions

Which is better-rated, Mellaril-S or Prochlorperazine?

Mellaril-S and Prochlorperazine are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Mellaril-S or Prochlorperazine?

Prochlorperazine costs pharmacies less to acquire — about $5.22 vs $22.23 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mellaril-S and Prochlorperazine?

Mellaril-S contains Thioridazine, while Prochlorperazine contains Prochlorperazine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.