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Melatonin vs UNISOM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Rating

New
64/100

Pharmacy pays

Type

SUPPLEMENT
RX

Active ingredient

Melatonin
DOXYLAMINE SUCCINATE

Manufacturer

Dosage forms

Liquid
Capsule, Tablet

Drug class

Antihistamine

Boxed warning

None
None

Treats

Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

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Frequently asked questions

What is the difference between Melatonin and Unisom?

Melatonin contains Melatonin, while Unisom contains Doxylamine Succinate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.