MEGESTROL ACETATE vs SKYLA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. MEGESTROL ACETATE and SKYLA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MEGESTROL ACETATE	SKYLA
Rating	70/100	New
Pharmacy pays	~$7.14 /30	~$192.31 /30
Type	RX	RX
Active ingredient	MEGESTROL ACETATE	LEVONORGESTREL
Manufacturer	Novitium Pharma	Bayer Hlthcare
Dosage forms	Tablet, Suspension	IUD
Drug class	Progestin	Progestin
Boxed warning	None	None
Half-life	—	about 36 hours (36 ± 13 hours at steady state)
Treats	Anorexia, Breast Neoplasms, Cachexia	—

megestrol acetate skyla

Rating

70/100

New

Pharmacy pays

~$7.14 /30

~$192.31 /30

Type

Active ingredient

MEGESTROL ACETATE

LEVONORGESTREL

Manufacturer

Novitium Pharma

Bayer Hlthcare

Dosage forms

Tablet, Suspension

IUD

Drug class

Progestin

Boxed warning

None

Half-life

—

about 36 hours (36 ± 13 hours at steady state)

Treats

Anorexia, Breast Neoplasms, Cachexia

—

Frequently asked questions

Which is cheaper, Megestrol Acetate or Skyla?

Megestrol Acetate costs pharmacies less to acquire — about $7.14 vs $192.31 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Megestrol Acetate and Skyla?

Megestrol Acetate contains Megestrol Acetate, while Skyla contains Levonorgestrel — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.