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MEGESTROL ACETATE vs PROVERA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. MEGESTROL ACETATE and PROVERA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
64/100

Pharmacy pays

~$7.14 /30
~$562.79 /30

Type

RX
RX

Active ingredient

MEGESTROL ACETATE
MEDROXYPROGESTERONE ACETATE

Dosage forms

Tablet, Suspension
Tablet

Drug class

Progestin
Progestin

Boxed warning

Treats

Anorexia, Breast Neoplasms, Cachexia
Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma

Frequently asked questions

Which is better-rated, Megestrol Acetate or Provera?

By our independent rating, Megestrol Acetate scores higher — 3.5 vs 3.2 out of 5 for Provera. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Megestrol Acetate or Provera?

Megestrol Acetate costs pharmacies less to acquire — about $7.14 vs $562.79 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Megestrol Acetate and Provera?

Megestrol Acetate contains Megestrol Acetate, while Provera contains Medroxyprogesterone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.