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MARCAINE vs XYLOCAINE VISCOUS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. MARCAINE and XYLOCAINE VISCOUS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

60/100
68/100

Pharmacy pays

$0.06 /mL
$0.24 /mL

Type

RX
RX

Active ingredient

BUPIVACAINE HYDROCHLORIDE
LIDOCAINE HYDROCHLORIDE

Dosage forms

Injectable
Solution

Drug class

Amide Local Anesthetic
Amide Local Anesthetic

Boxed warning

None
None

Treats

Postoperative Pain
Burns, Esophageal Diseases, Mouth Diseases

Frequently asked questions

Which is better-rated, Marcaine or Xylocaine Viscous?

By our independent rating, Xylocaine Viscous scores higher — 3.4 vs 3.0 out of 5 for Marcaine. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Marcaine or Xylocaine Viscous?

Marcaine costs pharmacies less to acquire — about $0.06 vs $0.24 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Marcaine and Xylocaine Viscous?

Marcaine contains Bupivacaine Hydrochloride, while Xylocaine Viscous contains Lidocaine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.