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LUPRON vs LUPRON DEPOT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

~$6171.24 /30
~$6171.24 /30

Type

RX
RX

Active ingredient

LEUPROLIDE ACETATE
LEUPROLIDE ACETATE

Dosage forms

Solution
Kit

Drug class

Gonadotropin Releasing Hormone Receptor Agonist
Gonadotropin Releasing Hormone Receptor Agonist

Boxed warning

None
None

Treats

Breast Neoplasms, Endometriosis, Infertility
Breast Neoplasms, Endometriosis, Infertility

Frequently asked questions

Which is cheaper, Lupron or Lupron Depot?

Pharmacies pay about the same to acquire either one — roughly $6171.24 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Lupron and Lupron Depot?

Both Lupron and Lupron Depot share the active ingredient Leuprolide Acetate.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.