LUPRON DEPOT vs SYNAREL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. LUPRON DEPOT and SYNAREL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LUPRON DEPOT	SYNAREL
Rating	New	64/100
Pharmacy pays	~$6171.24 /30	—
Type	RX	RX
Active ingredient	LEUPROLIDE ACETATE	NAFARELIN ACETATE
Manufacturer	Abbvie Endocrine Inc	Pfizer
Dosage forms	Kit	Spray/Inhaler, metered
Drug class	Gonadotropin Releasing Hormone Receptor Agonist	—
Boxed warning	None	None
Treats	Breast Neoplasms, Endometriosis, Infertility	Endometriosis, Precocious Puberty

lupron depot synarel

Rating

New

64/100

Pharmacy pays

~$6171.24 /30

—

Type

Active ingredient

LEUPROLIDE ACETATE

NAFARELIN ACETATE

Manufacturer

Abbvie Endocrine Inc

Pfizer

Dosage forms

Kit

Spray/Inhaler, metered

Drug class

Gonadotropin Releasing Hormone Receptor Agonist

—

Boxed warning

None

Treats

Breast Neoplasms, Endometriosis, Infertility

Endometriosis, Precocious Puberty

Frequently asked questions

What is the difference between Lupron Depot and Synarel?

Lupron Depot contains Leuprolide Acetate, while Synarel contains Nafarelin Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.