LUPKYNIS vs RESTASIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. LUPKYNIS and RESTASIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LUPKYNIS	RESTASIS
Rating	New	72/100
Pharmacy pays	—	~$52.85 /30
Type	RX	RX
Active ingredient	VOCLOSPORIN	CYCLOSPORINE
Manufacturer	Aurinia	Allergan
Dosage forms	Capsule	Emulsion
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	None	None
Half-life	—	about 8.4 hours (range 5 to 18 hours)
Treats	Lupus Nephritis	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

lupkynis restasis

Rating

New

72/100

Pharmacy pays

—

~$52.85 /30

Type

Active ingredient

VOCLOSPORIN

CYCLOSPORINE

Manufacturer

Aurinia

Allergan

Dosage forms

Capsule

Emulsion

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

None

Half-life

—

about 8.4 hours (range 5 to 18 hours)

Treats

Lupus Nephritis

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Frequently asked questions

What is the difference between Lupkynis and Restasis?

Lupkynis contains Voclosporin, while Restasis contains Cyclosporine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.