LUPKYNIS vs PROTOPIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. LUPKYNIS and PROTOPIC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LUPKYNIS	PROTOPIC
Rating	New	New
Pharmacy pays	—	$0.65 /g
Type	RX	RX
Active ingredient	VOCLOSPORIN	TACROLIMUS
Manufacturer	Aurinia	Leo Pharma As
Dosage forms	Capsule	Topical
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	None	None
Treats	Lupus Nephritis	Atopic Dermatitis, Graft Vs Host Disease

lupkynis protopic

Rating

New

Pharmacy pays

—

$0.65 /g

Type

Active ingredient

VOCLOSPORIN

TACROLIMUS

Manufacturer

Aurinia

Leo Pharma As

Dosage forms

Capsule

Topical

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

None

Treats

Lupus Nephritis

Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

What is the difference between Lupkynis and Protopic?

Lupkynis contains Voclosporin, while Protopic contains Tacrolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.