LUPKYNIS vs PROGRAF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. LUPKYNIS and PROGRAF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LUPKYNIS	PROGRAF
Rating	New	72/100
Pharmacy pays	—	$0.65 /g
Type	RX	RX
Active ingredient	VOCLOSPORIN	TACROLIMUS
Manufacturer	Aurinia	Astellas
Dosage forms	Capsule	Capsule, Powder, Injectable
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	None	Boxed warning
Treats	Lupus Nephritis	Atopic Dermatitis, Graft Vs Host Disease

lupkynis prograf

Rating

New

72/100

Pharmacy pays

—

$0.65 /g

Type

Active ingredient

VOCLOSPORIN

TACROLIMUS

Manufacturer

Aurinia

Astellas

Dosage forms

Capsule

Capsule, Powder, Injectable

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

None

Boxed warning

Treats

Lupus Nephritis

Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

What is the difference between Lupkynis and Prograf?

Lupkynis contains Voclosporin, while Prograf contains Tacrolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.