LOTRONEX vs ORILISSA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. LOTRONEX and ORILISSA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LOTRONEX	ORILISSA
Rating	New	72/100
Pharmacy pays	~$93.41 /30	—
Type	RX	RX
Active ingredient	ALOSETRON HYDROCHLORIDE	ELAGOLIX SODIUM
Manufacturer	Legacy Pharma	Abbvie
Dosage forms	Tablet	Tablet
Drug class	—	—
Boxed warning	Boxed warning	None
Treats	Diarrhea, Abdominal Pain, Irritable Bowel Syndrome	Abdominal Pain

lotronex orilissa

Rating

New

72/100

Pharmacy pays

~$93.41 /30

—

Type

Active ingredient

ALOSETRON HYDROCHLORIDE

ELAGOLIX SODIUM

Manufacturer

Legacy Pharma

Abbvie

Dosage forms

Tablet

Drug class

—

Boxed warning

None

Treats

Diarrhea, Abdominal Pain, Irritable Bowel Syndrome

Abdominal Pain

Frequently asked questions

What is the difference between Lotronex and Orilissa?

Lotronex contains Alosetron Hydrochloride, while Orilissa contains Elagolix Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.