LOTRIMIN vs TOLSURA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. LOTRIMIN and TOLSURA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LOTRIMIN	TOLSURA
Rating	New	70/100
Pharmacy pays	$0.21 /mL	$0.84 /mL
Type	RX	RX
Active ingredient	CLOTRIMAZOLE	ITRACONAZOLE
Manufacturer	Schering Plough	Mayne Pharma
Dosage forms	Topical	Capsule
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	Boxed warning
Half-life	—	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.
Treats	Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

lotrimin tolsura

Rating

New

70/100

Pharmacy pays

$0.21 /mL

$0.84 /mL

Type

Active ingredient

CLOTRIMAZOLE

ITRACONAZOLE

Manufacturer

Schering Plough

Mayne Pharma

Dosage forms

Topical

Capsule

Drug class

Azole Antifungal

Boxed warning

None

Boxed warning

Half-life

—

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

Treats

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

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Frequently asked questions

Which is cheaper, Lotrimin or Tolsura?

Lotrimin costs pharmacies less to acquire — about $0.21 vs $0.84 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lotrimin and Tolsura?

Lotrimin contains Clotrimazole, while Tolsura contains Itraconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.