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LOTREL vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. LOTREL and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
74/100

Pharmacy pays

~$0.33 /30
~$2.89 /30

Type

RX
RX

Active ingredient

AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE
PRIMIDONE

Dosage forms

Capsule
Tablet

Drug class

—
Anti-Epileptic Agent

Boxed warning

Half-life

about 30 to 50 hours
—

Treats

—
Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Lotrel or Mysoline?

By our independent rating, Mysoline scores higher — 3.7 vs 3.4 out of 5 for Lotrel. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Lotrel or Mysoline?

Lotrel costs pharmacies less to acquire — about $0.33 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lotrel and Mysoline?

Lotrel contains Amlodipine Besylate and Benazepril Hydrochloride, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.