LORBRENA vs SPRYCEL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. LORBRENA and SPRYCEL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LORBRENA	SPRYCEL
Rating	64/100	72/100
Pharmacy pays	—	~$839.19 /30
Type	RX	RX
Active ingredient	LORLATINIB	DASATINIB
Manufacturer	Pfizer	Bristol Myers Squibb
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Treats	—	Lymphoid Leukemia, Myeloid Leukemia

lorbrena sprycel

Rating

64/100

72/100

Pharmacy pays

—

~$839.19 /30

Type

Active ingredient

LORLATINIB

DASATINIB

Manufacturer

Pfizer

Bristol Myers Squibb

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

—

Lymphoid Leukemia, Myeloid Leukemia

Frequently asked questions

Which is better-rated, Lorbrena or Sprycel?

By our independent rating, Sprycel scores higher — 3.6 vs 3.2 out of 5 for Lorbrena. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Lorbrena and Sprycel?

Lorbrena contains Lorlatinib, while Sprycel contains Dasatinib — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.