LORAZEPAM vs LUNESTA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

Possible drug interaction. LORAZEPAM and LUNESTA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LORAZEPAM	LUNESTA
Rating	72/100	New
Pharmacy pays	~$1.14 /30	~$2.70 /30
Type	RX	RX
Active ingredient	LORAZEPAM	ESZOPICLONE
Manufacturer	Ani Pharms	Waylis Therap
Dosage forms	Injectable, Solution, Liquid, Tablet	Tablet
Drug class	Benzodiazepine	—
Boxed warning	Boxed warning	Boxed warning
Half-life	about 12 hours (mean)	—
Treats	Anxiety Disorders, Catatonia, Depressive Disorder	Sleep Initiation and Maintenance Disorders

lorazepam lunesta

Rating

72/100

New

Pharmacy pays

~$1.14 /30

~$2.70 /30

Type

Active ingredient

LORAZEPAM

ESZOPICLONE

Manufacturer

Ani Pharms

Waylis Therap

Dosage forms

Injectable, Solution, Liquid, Tablet

Tablet

Drug class

Benzodiazepine

—

Boxed warning

Half-life

about 12 hours (mean)

—

Treats

Anxiety Disorders, Catatonia, Depressive Disorder

Sleep Initiation and Maintenance Disorders

Frequently asked questions

Which is cheaper, Lorazepam or Lunesta?

Lorazepam costs pharmacies less to acquire — about $1.14 vs $2.70 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lorazepam and Lunesta?

Lorazepam contains Lorazepam, while Lunesta contains Eszopiclone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.