LOPERAMIDE HYDROCHLORIDE vs ULTRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. LOPERAMIDE HYDROCHLORIDE and ULTRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LOPERAMIDE HYDROCHLORIDE	ULTRAM
Rating	70/100	70/100
Pharmacy pays	$0.05 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE
Manufacturer	Jubilant Cadista	Janssen Pharms
Dosage forms	Capsule	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Pain

loperamide hydrochloride ultram

Rating

70/100

Pharmacy pays

$0.05 /mL

~$0.72 /30

Type

Active ingredient

LOPERAMIDE HYDROCHLORIDE

TRAMADOL HYDROCHLORIDE

Manufacturer

Jubilant Cadista

Janssen Pharms

Dosage forms

Capsule

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Pain

Frequently asked questions

Which is better-rated, Loperamide Hydrochloride or Ultram?

Loperamide Hydrochloride and Ultram are tied at 3.5 out of 5 by our independent rating.

What is the difference between Loperamide Hydrochloride and Ultram?

Loperamide Hydrochloride contains Loperamide Hydrochloride, while Ultram contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.