LOPERAMIDE HYDROCHLORIDE vs OPANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. LOPERAMIDE HYDROCHLORIDE and OPANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LOPERAMIDE HYDROCHLORIDE	OPANA
Rating	70/100	72/100
Pharmacy pays	$0.05 /mL	~$36.74 /30
Type	RX	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Jubilant Cadista	Endo Pharms
Dosage forms	Capsule	Tablet, Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	—
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Pain

loperamide hydrochloride opana

Rating

70/100

72/100

Pharmacy pays

$0.05 /mL

~$36.74 /30

Type

Active ingredient

LOPERAMIDE HYDROCHLORIDE

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Jubilant Cadista

Endo Pharms

Dosage forms

Capsule

Tablet, Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

—

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Pain

Frequently asked questions

Which is better-rated, Loperamide Hydrochloride or Opana?

By our independent rating, Opana scores higher — 3.6 vs 3.5 out of 5 for Loperamide Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Loperamide Hydrochloride and Opana?

Loperamide Hydrochloride contains Loperamide Hydrochloride, while Opana contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.