LOPERAMIDE HYDROCHLORIDE vs NUCYNTA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. LOPERAMIDE HYDROCHLORIDE and NUCYNTA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LOPERAMIDE HYDROCHLORIDE	NUCYNTA
Rating	70/100	New
Pharmacy pays	$0.05 /mL	~$342.56 /30
Type	RX	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	TAPENTADOL HYDROCHLORIDE
Manufacturer	Jubilant Cadista	Collegium Pharm Inc
Dosage forms	Capsule	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Pain

loperamide hydrochloride nucynta

Rating

70/100

New

Pharmacy pays

$0.05 /mL

~$342.56 /30

Type

Active ingredient

LOPERAMIDE HYDROCHLORIDE

TAPENTADOL HYDROCHLORIDE

Manufacturer

Jubilant Cadista

Collegium Pharm Inc

Dosage forms

Capsule

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Pain

Frequently asked questions

What is the difference between Loperamide Hydrochloride and Nucynta?

Loperamide Hydrochloride contains Loperamide Hydrochloride, while Nucynta contains Tapentadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.