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LOPERAMIDE HYDROCHLORIDE vs METHADOSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. LOPERAMIDE HYDROCHLORIDE and METHADOSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

loperamide hydrochloridemethadose

Rating

70/100
70/100

Pharmacy pays

$0.05 /mL
$0.18 /mL

Type

RX
RX

Active ingredient

LOPERAMIDE HYDROCHLORIDE
METHADONE HYDROCHLORIDE

Manufacturer

Jubilant Cadista
Specgx LLC

Dosage forms

Capsule
—

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Boxed warning
Boxed warning

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)
about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery
Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is better-rated, Loperamide Hydrochloride or Methadose?

Loperamide Hydrochloride and Methadose are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Loperamide Hydrochloride or Methadose?

Loperamide Hydrochloride costs pharmacies less to acquire — about $0.05 vs $0.18 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Loperamide Hydrochloride and Methadose?

Loperamide Hydrochloride contains Loperamide Hydrochloride, while Methadose contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.