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LONSURF vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated September 26, 2026·How we rate

Possible drug interaction. LONSURF and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
74/100

Pharmacy pays

—
$1.04 /g

Type

RX
RX

Active ingredient

TIPIRACIL HYDROCHLORIDE AND TRIFLURIDINE
TRETINOIN

Dosage forms

Tablet
Topical

Drug class

—
Retinoid

Boxed warning

None
None

Treats

—
Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

What is the difference between Lonsurf and Retin-A?

Lonsurf contains Tipiracil Hydrochloride and Trifluridine, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.