LODINE vs VOLTAREN-XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. LODINE and VOLTAREN-XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LODINE	VOLTAREN-XR
Rating	New	70/100
Pharmacy pays	~$22.58 /30	$0.36 /mL
Type	RX	RX
Active ingredient	ETODOLAC	DICLOFENAC SODIUM
Manufacturer	Wyeth Pharms Inc	Novartis
Dosage forms	Tablet, Capsule	Tablet, extended release
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Rheumatoid Arthritis, Osteoarthritis, Pain	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

lodine voltaren-xr

Rating

New

70/100

Pharmacy pays

~$22.58 /30

$0.36 /mL

Type

Active ingredient

ETODOLAC

DICLOFENAC SODIUM

Manufacturer

Wyeth Pharms Inc

Novartis

Dosage forms

Tablet, Capsule

Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Rheumatoid Arthritis, Osteoarthritis, Pain

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

What is the difference between Lodine and Voltaren-XR?

Lodine contains Etodolac, while Voltaren-XR contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.