LODINE vs NUPRIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. LODINE and NUPRIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LODINE	NUPRIN
Rating	New	70/100
Pharmacy pays	~$22.58 /30	$0.04 /mL
Type	RX	RX
Active ingredient	ETODOLAC	IBUPROFEN
Manufacturer	Wyeth Pharms Inc	Kenvue Brands
Dosage forms	Tablet, Capsule	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)	about 1.8 to 2.0 hours
Treats	Rheumatoid Arthritis, Osteoarthritis, Pain	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

lodine nuprin

Rating

New

70/100

Pharmacy pays

~$22.58 /30

$0.04 /mL

Type

Active ingredient

ETODOLAC

IBUPROFEN

Manufacturer

Wyeth Pharms Inc

Kenvue Brands

Dosage forms

Tablet, Capsule

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)

about 1.8 to 2.0 hours

Treats

Rheumatoid Arthritis, Osteoarthritis, Pain

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Frequently asked questions

What is the difference between Lodine and Nuprin?

Lodine contains Etodolac, while Nuprin contains Ibuprofen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.