LISDEXAMFETAMINE DIMESYLATE vs METHYLPHENIDATE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. LISDEXAMFETAMINE DIMESYLATE and METHYLPHENIDATE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LISDEXAMFETAMINE DIMESYLATE	METHYLPHENIDATE HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	—	~$18.94 /30
Type	RX	RX
Active ingredient	LISDEXAMFETAMINE DIMESYLATE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Ascent Pharms Inc	Alkem Labs Ltd
Dosage forms	Capsule, Tablet, chewable	Capsule, extended release, Solution, Tablet, Tablet, chewable, Tablet, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	None
Half-life	less than 1 hour (parent drug)	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Binge Drinking	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

lisdexamfetamine dimesylate methylphenidate hydrochloride

Rating

70/100

New

Pharmacy pays

—

~$18.94 /30

Type

Active ingredient

LISDEXAMFETAMINE DIMESYLATE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Ascent Pharms Inc

Alkem Labs Ltd

Dosage forms

Capsule, Tablet, chewable

Capsule, extended release, Solution, Tablet, Tablet, chewable, Tablet, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

None

Half-life

less than 1 hour (parent drug)

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

What is the difference between Lisdexamfetamine Dimesylate and Methylphenidate Hydrochloride?

Lisdexamfetamine Dimesylate contains Lisdexamfetamine Dimesylate, while Methylphenidate Hydrochloride contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.