LINZESS vs VIBERZI

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. LINZESS and VIBERZI are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LINZESS	VIBERZI
Rating	70/100	72/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	LINACLOTIDE	ELUXADOLINE
Manufacturer	Abbvie	Abbvie
Dosage forms	Capsule	Tablet
Drug class	Guanylate Cyclase-C Agonist	—
Boxed warning	Boxed warning	None
Treats	Constipation, Irritable Bowel Syndrome	Irritable Bowel Syndrome

linzess viberzi

Rating

70/100

72/100

Pharmacy pays

—

Type

Active ingredient

LINACLOTIDE

ELUXADOLINE

Manufacturer

Abbvie

Dosage forms

Capsule

Tablet

Drug class

Guanylate Cyclase-C Agonist

—

Boxed warning

None

Treats

Constipation, Irritable Bowel Syndrome

Irritable Bowel Syndrome

Frequently asked questions

Which is better-rated, Linzess or Viberzi?

By our independent rating, Viberzi scores higher — 3.6 vs 3.5 out of 5 for Linzess. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Linzess and Viberzi?

Linzess contains Linaclotide, while Viberzi contains Eluxadoline — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.