LINZESS vs MOTEGRITY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. LINZESS and MOTEGRITY are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LINZESS	MOTEGRITY
Rating	70/100	New
Pharmacy pays	—	~$21.22 /30
Type	RX	RX
Active ingredient	LINACLOTIDE	PRUCALOPRIDE SUCCINATE
Manufacturer	Abbvie	Takeda Pharms USA
Dosage forms	Capsule	Tablet
Drug class	Guanylate Cyclase-C Agonist	Serotonin-4 Receptor Agonist
Boxed warning	Boxed warning	None
Treats	Constipation, Irritable Bowel Syndrome	Constipation

linzess motegrity

Rating

70/100

New

Pharmacy pays

—

~$21.22 /30

Type

Active ingredient

LINACLOTIDE

PRUCALOPRIDE SUCCINATE

Manufacturer

Abbvie

Takeda Pharms USA

Dosage forms

Capsule

Tablet

Drug class

Guanylate Cyclase-C Agonist

Serotonin-4 Receptor Agonist

Boxed warning

None

Treats

Constipation, Irritable Bowel Syndrome

Constipation

Frequently asked questions

What is the difference between Linzess and Motegrity?

Linzess contains Linaclotide, while Motegrity contains Prucalopride Succinate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.