LILETTA vs MEGESTROL ACETATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. LILETTA and MEGESTROL ACETATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LILETTA	MEGESTROL ACETATE
Rating	New	70/100
Pharmacy pays	~$192.31 /30	~$7.14 /30
Type	RX	RX
Active ingredient	LEVONORGESTREL	MEGESTROL ACETATE
Manufacturer	Medicines360	Novitium Pharma
Dosage forms	IUD	Tablet, Suspension
Drug class	Progestin	Progestin
Boxed warning	None	None
Half-life	about 36 hours (36 ± 13 hours at steady state)	—
Treats	—	Anorexia, Breast Neoplasms, Cachexia

liletta megestrol acetate

Rating

New

70/100

Pharmacy pays

~$192.31 /30

~$7.14 /30

Type

Active ingredient

LEVONORGESTREL

MEGESTROL ACETATE

Manufacturer

Medicines360

Novitium Pharma

Dosage forms

IUD

Tablet, Suspension

Drug class

Progestin

Boxed warning

None

Half-life

about 36 hours (36 ± 13 hours at steady state)

—

Treats

—

Anorexia, Breast Neoplasms, Cachexia

Frequently asked questions

Which is cheaper, Liletta or Megestrol Acetate?

Megestrol Acetate costs pharmacies less to acquire — about $7.14 vs $192.31 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Liletta and Megestrol Acetate?

Liletta contains Levonorgestrel, while Megestrol Acetate contains Megestrol Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.