LIDOCAINE vs LIDOCAINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. LIDOCAINE and LIDOCAINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LIDOCAINE	LIDOCAINE HYDROCHLORIDE
Rating	New	60/100
Pharmacy pays	$0.24 /mL	$0.24 /mL
Type	RX	RX
Active ingredient	LIDOCAINE	LIDOCAINE HYDROCHLORIDE
Manufacturer	Geneyork Pharms	Hospira
Dosage forms	Topical, Injectable, Patch	Injectable, Solution, Topical, Jelly, Liquid, Spray/Inhaler
Drug class	Amide Local Anesthetic	Amide Local Anesthetic
Boxed warning	None	None
Treats	Burns, Esophageal Diseases, Mouth Diseases	Burns, Esophageal Diseases, Mouth Diseases

lidocaine lidocaine hydrochloride

Rating

New

60/100

Pharmacy pays

$0.24 /mL

Type

Active ingredient

LIDOCAINE

LIDOCAINE HYDROCHLORIDE

Manufacturer

Geneyork Pharms

Hospira

Dosage forms

Topical, Injectable, Patch

Injectable, Solution, Topical, Jelly, Liquid, Spray/Inhaler

Drug class

Amide Local Anesthetic

Boxed warning

None

Treats

Burns, Esophageal Diseases, Mouth Diseases

Frequently asked questions

Which is cheaper, Lidocaine or Lidocaine Hydrochloride?

Pharmacies pay about the same to acquire either one — roughly $0.24 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Lidocaine and Lidocaine Hydrochloride?

Lidocaine contains Lidocaine, while Lidocaine Hydrochloride contains Lidocaine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.