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LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE vs MARCAINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE and MARCAINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

lidocaine hydrochloride preservative freemarcaine

Rating

72/100
60/100

Pharmacy pays

$0.26 /mL
$0.06 /mL

Type

RX
RX

Active ingredient

LIDOCAINE HYDROCHLORIDE
BUPIVACAINE HYDROCHLORIDE

Manufacturer

Hikma
Hospira

Dosage forms

Injectable
Injectable

Drug class

Amide Local Anesthetic
Amide Local Anesthetic

Boxed warning

None
None

Treats

Burns, Esophageal Diseases, Mouth Diseases
Postoperative Pain

Frequently asked questions

Which is better-rated, Lidocaine Hydrochloride Preservative Free or Marcaine?

By our independent rating, Lidocaine Hydrochloride Preservative Free scores higher — 3.6 vs 3.0 out of 5 for Marcaine. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Lidocaine Hydrochloride Preservative Free or Marcaine?

Marcaine costs pharmacies less to acquire — about $0.06 vs $0.26 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lidocaine Hydrochloride Preservative Free and Marcaine?

Lidocaine Hydrochloride Preservative Free contains Lidocaine Hydrochloride, while Marcaine contains Bupivacaine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.