LETAIRIS vs ORENITRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. LETAIRIS and ORENITRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LETAIRIS	ORENITRAM
Rating	70/100	New
Pharmacy pays	~$255.61 /30	—
Type	RX	RX
Active ingredient	AMBRISENTAN	TREPROSTINIL DIOLAMINE
Manufacturer	Gilead Sciences Inc	United Therap
Dosage forms	Tablet	Tablet, extended release, Kit
Drug class	Endothelin Receptor Antagonist	—
Boxed warning	Boxed warning	None
Treats	Pulmonary Hypertension	Pulmonary Hypertension

letairis orenitram

Rating

70/100

New

Pharmacy pays

~$255.61 /30

—

Type

Active ingredient

AMBRISENTAN

TREPROSTINIL DIOLAMINE

Manufacturer

Gilead Sciences Inc

United Therap

Dosage forms

Tablet

Tablet, extended release, Kit

Drug class

Endothelin Receptor Antagonist

—

Boxed warning

None

Treats

Pulmonary Hypertension

Frequently asked questions

What is the difference between Letairis and Orenitram?

Letairis contains Ambrisentan, while Orenitram contains Treprostinil Diolamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.