LETAIRIS vs MACITENTAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. LETAIRIS and MACITENTAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LETAIRIS	MACITENTAN
Rating	70/100	66/100
Pharmacy pays	~$255.61 /30	—
Type	RX	RX
Active ingredient	AMBRISENTAN	MACITENTAN
Manufacturer	Gilead Sciences Inc	Torrent
Dosage forms	Tablet	Tablet
Drug class	Endothelin Receptor Antagonist	Endothelin Receptor Antagonist
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 16 hours (apparent elimination half-life)
Treats	Pulmonary Hypertension	Pulmonary Hypertension

letairis macitentan

Rating

70/100

66/100

Pharmacy pays

~$255.61 /30

—

Type

Active ingredient

AMBRISENTAN

MACITENTAN

Manufacturer

Gilead Sciences Inc

Torrent

Dosage forms

Tablet

Drug class

Endothelin Receptor Antagonist

Boxed warning

Half-life

—

about 16 hours (apparent elimination half-life)

Treats

Pulmonary Hypertension

Frequently asked questions

Which is better-rated, Letairis or Macitentan?

By our independent rating, Letairis scores higher — 3.5 vs 3.3 out of 5 for Macitentan. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Letairis and Macitentan?

Letairis contains Ambrisentan, while Macitentan contains Macitentan — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.