LAMICTAL vs ZONISADE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. LAMICTAL and ZONISADE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LAMICTAL	ZONISADE
Rating	70/100	70/100
Pharmacy pays	~$4.39 /30	~$3.16 /30
Type	RX	RX
Active ingredient	LAMOTRIGINE	ZONISAMIDE
Manufacturer	Glaxosmithkline	Azurity
Dosage forms	Tablet, Kit	Suspension
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	Boxed warning	None
Half-life	about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism	—
Treats	Bipolar Disorder, Partial Epilepsies, Seizures	Partial Epilepsies

lamictal zonisade

Rating

70/100

Pharmacy pays

~$4.39 /30

~$3.16 /30

Type

Active ingredient

LAMOTRIGINE

ZONISAMIDE

Manufacturer

Glaxosmithkline

Azurity

Dosage forms

Tablet, Kit

Suspension

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism

—

Treats

Bipolar Disorder, Partial Epilepsies, Seizures

Partial Epilepsies

Frequently asked questions

Which is better-rated, Lamictal or Zonisade?

Lamictal and Zonisade are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Lamictal or Zonisade?

Zonisade costs pharmacies less to acquire — about $3.16 vs $4.39 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lamictal and Zonisade?

Lamictal contains Lamotrigine, while Zonisade contains Zonisamide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.