LAMICTAL vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. LAMICTAL and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LAMICTAL	MYSOLINE
Rating	70/100	70/100
Pharmacy pays	~$4.39 /30	~$2.89 /30
Type	RX	RX
Active ingredient	LAMOTRIGINE	PRIMIDONE
Manufacturer	Glaxosmithkline	Valeant Pharm Intl
Dosage forms	Tablet, Kit	Tablet
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	Boxed warning	None
Half-life	about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism	—
Treats	Bipolar Disorder, Partial Epilepsies, Seizures	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

lamictal mysoline

Rating

70/100

Pharmacy pays

~$4.39 /30

~$2.89 /30

Type

Active ingredient

LAMOTRIGINE

PRIMIDONE

Manufacturer

Glaxosmithkline

Valeant Pharm Intl

Dosage forms

Tablet, Kit

Tablet

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism

—

Treats

Bipolar Disorder, Partial Epilepsies, Seizures

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Lamictal or Mysoline?

Lamictal and Mysoline are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Lamictal or Mysoline?

Mysoline costs pharmacies less to acquire — about $2.89 vs $4.39 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lamictal and Mysoline?

Lamictal contains Lamotrigine, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.