LACTULOSE vs LINZESS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

Possible drug interaction. LACTULOSE and LINZESS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LACTULOSE	LINZESS
Rating	66/100	70/100
Pharmacy pays	~$0.72 /30	—
Type	RX	RX
Active ingredient	LACTULOSE	LINACLOTIDE
Manufacturer	Fresenius Kabi USA	Abbvie
Dosage forms	Solution, Powder	Capsule
Drug class	Osmotic Laxative	Guanylate Cyclase-C Agonist
Boxed warning	None	Boxed warning
Treats	Constipation, Hepatic Encephalopathy	Constipation, Irritable Bowel Syndrome

lactulose linzess

Rating

66/100

70/100

Pharmacy pays

~$0.72 /30

—

Type

Active ingredient

LACTULOSE

LINACLOTIDE

Manufacturer

Fresenius Kabi USA

Abbvie

Dosage forms

Solution, Powder

Capsule

Drug class

Osmotic Laxative

Guanylate Cyclase-C Agonist

Boxed warning

None

Boxed warning

Treats

Constipation, Hepatic Encephalopathy

Constipation, Irritable Bowel Syndrome

Frequently asked questions

Which is better-rated, Lactulose or Linzess?

By our independent rating, Linzess scores higher — 3.5 vs 3.3 out of 5 for Lactulose. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Lactulose and Linzess?

Lactulose contains Lactulose, while Linzess contains Linaclotide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.