LACRISERT vs XIIDRA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. LACRISERT and XIIDRA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LACRISERT	XIIDRA
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	HYDROXYPROPYL CELLULOSE	LIFITEGRAST
Manufacturer	Bausch and Lomb	Bausch and Lomb
Dosage forms	Insert	Drops
Drug class	—	Lymphocyte Function-Associated Antigen-1 Antagonist
Boxed warning	None	None
Treats	Keratitis, Dry Eye Syndromes	Dry Eye Syndromes

lacrisert xiidra

Rating

New

Pharmacy pays

—

Type

Active ingredient

HYDROXYPROPYL CELLULOSE

LIFITEGRAST

Manufacturer

Bausch and Lomb

Dosage forms

Insert

Drops

Drug class

—

Lymphocyte Function-Associated Antigen-1 Antagonist

Boxed warning

None

Treats

Keratitis, Dry Eye Syndromes

Dry Eye Syndromes

Frequently asked questions

What is the difference between Lacrisert and Xiidra?

Lacrisert contains Hydroxypropyl Cellulose, while Xiidra contains Lifitegrast — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.