KEYTRUDA vs OPDIVO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. KEYTRUDA and OPDIVO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	KEYTRUDA	OPDIVO
Rating	70/100	72/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	PEMBROLIZUMAB	NIVOLUMAB
Manufacturer	Merck Sharp Dohme	Bristol Myers Squibb
Dosage forms	Injectable	Injectable
Drug class	Programmed Death Receptor-1 Blocking Antibody	Programmed Death Receptor-1 Blocking Antibody
Boxed warning	None	None
Treats	Malignant Mesothelioma, Biliary Tract Neoplasms, Urinary Bladder Neoplasms	Urinary Bladder Neoplasms, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma

keytruda opdivo

Rating

70/100

72/100

Pharmacy pays

—

Type

Active ingredient

PEMBROLIZUMAB

NIVOLUMAB

Manufacturer

Merck Sharp Dohme

Bristol Myers Squibb

Dosage forms

Injectable

Drug class

Programmed Death Receptor-1 Blocking Antibody

Boxed warning

None

Treats

Malignant Mesothelioma, Biliary Tract Neoplasms, Urinary Bladder Neoplasms

Urinary Bladder Neoplasms, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma

Frequently asked questions

Which is better-rated, Keytruda or Opdivo?

By our independent rating, Opdivo scores higher — 3.6 vs 3.5 out of 5 for Keytruda. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Keytruda and Opdivo?

Keytruda contains Pembrolizumab, while Opdivo contains Nivolumab — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.