KAYEXALATE vs LOKELMA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. KAYEXALATE and LOKELMA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	KAYEXALATE	LOKELMA
Rating	New	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	SODIUM POLYSTYRENE SULFONATE	SODIUM ZIRCONIUM CYCLOSILICATE
Manufacturer	Concordia	Astrazeneca
Dosage forms	Powder	Powder
Drug class	—	—
Boxed warning	None	None
Treats	Hyperkalemia	Hyperkalemia

kayexalate lokelma

Rating

New

70/100

Pharmacy pays

—

Type

Active ingredient

SODIUM POLYSTYRENE SULFONATE

SODIUM ZIRCONIUM CYCLOSILICATE

Manufacturer

Concordia

Astrazeneca

Dosage forms

Powder

Drug class

—

Boxed warning

None

Treats

Hyperkalemia

Frequently asked questions

What is the difference between Kayexalate and Lokelma?

Kayexalate contains Sodium Polystyrene Sulfonate, while Lokelma contains Sodium Zirconium Cyclosilicate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.