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KALYDECO vs PULMOZYME

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. KALYDECO and PULMOZYME are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

Type

RX
RX

Active ingredient

IVACAFTOR
DORNASE ALFA

Dosage forms

Powder, Tablet
Solution

Drug class

Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
Recombinant Human Deoxyribonuclease 1

Boxed warning

None
None

Treats

Cystic Fibrosis
Bronchitis, Cystic Fibrosis

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Frequently asked questions

What is the difference between Kalydeco and Pulmozyme?

Kalydeco contains Ivacaftor, while Pulmozyme contains Dornase Alfa — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.