KALYDECO vs OLPRUVA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 30, 2026·How we rate

Possible drug interaction. KALYDECO and OLPRUVA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	KALYDECO	OLPRUVA
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	IVACAFTOR	SODIUM PHENYLBUTYRATE
Manufacturer	Vertex Pharms Inc	Acer
Dosage forms	Powder, Tablet	Kit
Drug class	Cystic Fibrosis Transmembrane Conductance Regulator Potentiator	Nitrogen Binding Agent
Boxed warning	None	None
Treats	Cystic Fibrosis	Sickle Cell Anemia, Cystic Fibrosis, Myeloproliferative Disorders

kalydeco olpruva

Rating

New

Pharmacy pays

—

Type

Active ingredient

IVACAFTOR

SODIUM PHENYLBUTYRATE

Manufacturer

Vertex Pharms Inc

Acer

Dosage forms

Powder, Tablet

Kit

Drug class

Cystic Fibrosis Transmembrane Conductance Regulator Potentiator

Nitrogen Binding Agent

Boxed warning

None

Treats

Cystic Fibrosis

Sickle Cell Anemia, Cystic Fibrosis, Myeloproliferative Disorders

Frequently asked questions

What is the difference between Kalydeco and Olpruva?

Kalydeco contains Ivacaftor, while Olpruva contains Sodium Phenylbutyrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.