KADIAN vs TRAMADOL HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. KADIAN and TRAMADOL HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	KADIAN	TRAMADOL HYDROCHLORIDE
Rating	72/100	New
Pharmacy pays	$2.61 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	MORPHINE SULFATE	TRAMADOL HYDROCHLORIDE
Manufacturer	Allergan	Cspc Ouyi
Dosage forms	Capsule, extended release	Tablet, Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 2 hours	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Dyspnea, Intractable Pain	Pain

kadian tramadol hydrochloride

Rating

72/100

New

Pharmacy pays

$2.61 /mL

~$0.72 /30

Type

Active ingredient

MORPHINE SULFATE

TRAMADOL HYDROCHLORIDE

Manufacturer

Allergan

Cspc Ouyi

Dosage forms

Capsule, extended release

Tablet, Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 2 hours

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Dyspnea, Intractable Pain

Pain

Frequently asked questions

What is the difference between Kadian and Tramadol Hydrochloride?

Kadian contains Morphine Sulfate, while Tramadol Hydrochloride contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.