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JYNARQUE vs SAMSCA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

~$586.88 /30
~$586.88 /30

Type

RX
RX

Active ingredient

TOLVAPTAN
TOLVAPTAN

Manufacturer

Dosage forms

Tablet
Tablet

Drug class

Vasopressin V2 Receptor Antagonist
Vasopressin V2 Receptor Antagonist

Treats

Hyponatremia
Hyponatremia

Frequently asked questions

Which is cheaper, Jynarque or Samsca?

Pharmacies pay about the same to acquire either one — roughly $586.88 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Jynarque and Samsca?

Both Jynarque and Samsca share the active ingredient Tolvaptan.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.