JAKAFI XR vs TOFACITINIB CITRATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. JAKAFI XR and TOFACITINIB CITRATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	JAKAFI XR	TOFACITINIB CITRATE
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	RUXOLITINIB PHOSPHATE	TOFACITINIB CITRATE
Manufacturer	Incyte Corp	Somerset Theraps LLC
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	Janus Kinase Inhibitor	Janus Kinase Inhibitor
Boxed warning	None	Boxed warning
Treats	Polycythemia Vera, Primary Myelofibrosis	Rheumatoid Arthritis

jakafi xr tofacitinib citrate

Rating

New

Pharmacy pays

—

Type

Active ingredient

RUXOLITINIB PHOSPHATE

TOFACITINIB CITRATE

Manufacturer

Incyte Corp

Somerset Theraps LLC

Dosage forms

Tablet, extended release

Drug class

Janus Kinase Inhibitor

Boxed warning

None

Boxed warning

Treats

Polycythemia Vera, Primary Myelofibrosis

Rheumatoid Arthritis

Frequently asked questions

What is the difference between Jakafi XR and Tofacitinib Citrate?

Jakafi XR contains Ruxolitinib Phosphate, while Tofacitinib Citrate contains Tofacitinib Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.