JAKAFI XR vs OPZELURA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	JAKAFI XR	OPZELURA
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	RUXOLITINIB PHOSPHATE	RUXOLITINIB PHOSPHATE
Manufacturer	Incyte Corp	Incyte Corp
Dosage forms	Tablet, extended release	Topical
Drug class	Janus Kinase Inhibitor	Janus Kinase Inhibitor
Boxed warning	None	Boxed warning
Treats	Polycythemia Vera, Primary Myelofibrosis	Polycythemia Vera, Primary Myelofibrosis

jakafi xr opzelura

Rating

New

Pharmacy pays

—

Type

Active ingredient

RUXOLITINIB PHOSPHATE

Manufacturer

Incyte Corp

Dosage forms

Tablet, extended release

Topical

Drug class

Janus Kinase Inhibitor

Boxed warning

None

Boxed warning

Treats

Polycythemia Vera, Primary Myelofibrosis

Frequently asked questions

What is the difference between Jakafi XR and Opzelura?

Both Jakafi XR and Opzelura share the active ingredient Ruxolitinib Phosphate.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.