IOPIDINE vs SUDAFED 12 HOUR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. IOPIDINE and SUDAFED 12 HOUR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	IOPIDINE	SUDAFED 12 HOUR
Rating	70/100	72/100
Pharmacy pays	$9.68 /mL	~$8.42 /30
Type	RX	RX
Active ingredient	APRACLONIDINE HYDROCHLORIDE	PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Harrow Eye	Glaxosmithkline
Dosage forms	Drops	Capsule, extended release, Tablet, extended release
Drug class	Alpha-Adrenergic Agonist	Alpha-Adrenergic Agonist
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Ocular Hypertension	Asthma, Common Cold, Perennial Allergic Rhinitis

iopidine sudafed 12 hour

Rating

70/100

72/100

Pharmacy pays

$9.68 /mL

~$8.42 /30

Type

Active ingredient

APRACLONIDINE HYDROCHLORIDE

PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Harrow Eye

Glaxosmithkline

Dosage forms

Drops

Capsule, extended release, Tablet, extended release

Drug class

Alpha-Adrenergic Agonist

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Ocular Hypertension

Asthma, Common Cold, Perennial Allergic Rhinitis

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Frequently asked questions

Which is better-rated, Iopidine or Sudafed 12 Hour?

By our independent rating, Sudafed 12 Hour scores higher — 3.6 vs 3.5 out of 5 for Iopidine. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Iopidine and Sudafed 12 Hour?

Iopidine contains Apraclonidine Hydrochloride, while Sudafed 12 Hour contains Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.