IOPIDINE vs NOVAFED

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. IOPIDINE and NOVAFED are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	IOPIDINE	NOVAFED
Rating	70/100	70/100
Pharmacy pays	$9.89 /mL	~$8.29 /30
Type	RX	RX
Active ingredient	APRACLONIDINE HYDROCHLORIDE	PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Harrow Eye	Sanofi Aventis US
Dosage forms	Drops	Capsule, extended release
Drug class	Alpha-Adrenergic Agonist	Alpha-Adrenergic Agonist
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Ocular Hypertension	Asthma, Common Cold, Perennial Allergic Rhinitis

iopidine novafed

Rating

70/100

Pharmacy pays

$9.89 /mL

~$8.29 /30

Type

Active ingredient

APRACLONIDINE HYDROCHLORIDE

PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Harrow Eye

Sanofi Aventis US

Dosage forms

Drops

Capsule, extended release

Drug class

Alpha-Adrenergic Agonist

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Ocular Hypertension

Asthma, Common Cold, Perennial Allergic Rhinitis

Get novafed

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Frequently asked questions

Which is better-rated, Iopidine or Novafed?

Iopidine and Novafed are tied at 3.5 out of 5 by our independent rating.

What is the difference between Iopidine and Novafed?

Iopidine contains Apraclonidine Hydrochloride, while Novafed contains Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.