INVEGA SUSTENNA vs ZYPREXA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. INVEGA SUSTENNA and ZYPREXA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INVEGA SUSTENNA	ZYPREXA
Rating	70/100	New
Pharmacy pays	—	~$4.13 /30
Type	RX	RX
Active ingredient	PALIPERIDONE PALMITATE	OLANZAPINE
Manufacturer	Janssen Pharms	Cheplapharm
Dosage forms	Injectable	Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 21 to 54 hours (mean around 30 hours)
Treats	Bipolar Disorder, Depressive Disorder, Schizophrenia	Bipolar Disorder, Psychotic Disorders, Schizophrenia

invega sustenna zyprexa

Rating

70/100

New

Pharmacy pays

—

~$4.13 /30

Type

Active ingredient

PALIPERIDONE PALMITATE

OLANZAPINE

Manufacturer

Janssen Pharms

Cheplapharm

Dosage forms

Injectable

Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

—

about 21 to 54 hours (mean around 30 hours)

Treats

Bipolar Disorder, Depressive Disorder, Schizophrenia

Bipolar Disorder, Psychotic Disorders, Schizophrenia

Frequently asked questions

What is the difference between Invega Sustenna and Zyprexa?

Invega Sustenna contains Paliperidone Palmitate, while Zyprexa contains Olanzapine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.