INVEGA SUSTENNA vs SEROQUEL XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. INVEGA SUSTENNA and SEROQUEL XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INVEGA SUSTENNA	SEROQUEL XR
Rating	70/100	New
Pharmacy pays	—	~$2.64 /30
Type	RX	RX
Active ingredient	PALIPERIDONE PALMITATE	QUETIAPINE FUMARATE
Manufacturer	Janssen Pharms	Cheplapharm Arzneimittel Gmbh
Dosage forms	Injectable	Tablet, extended release
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	None
Half-life	—	about 6 hours
Treats	Bipolar Disorder, Depressive Disorder, Schizophrenia	Autistic Disorder, Bipolar Disorder, Major Depressive Disorder

invega sustenna seroquel xr

Rating

70/100

New

Pharmacy pays

—

~$2.64 /30

Type

Active ingredient

PALIPERIDONE PALMITATE

QUETIAPINE FUMARATE

Manufacturer

Janssen Pharms

Cheplapharm Arzneimittel Gmbh

Dosage forms

Injectable

Tablet, extended release

Drug class

Atypical Antipsychotic

Boxed warning

None

Half-life

—

about 6 hours

Treats

Bipolar Disorder, Depressive Disorder, Schizophrenia

Autistic Disorder, Bipolar Disorder, Major Depressive Disorder

Frequently asked questions

What is the difference between Invega Sustenna and Seroquel XR?

Invega Sustenna contains Paliperidone Palmitate, while Seroquel XR contains Quetiapine Fumarate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.