INVEGA SUSTENNA vs REXULTI

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. INVEGA SUSTENNA and REXULTI are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INVEGA SUSTENNA	REXULTI
Rating	70/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	PALIPERIDONE PALMITATE	BREXPIPRAZOLE
Manufacturer	Janssen Pharms	Otsuka
Dosage forms	Injectable	Tablet, Kit
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Treats	Bipolar Disorder, Depressive Disorder, Schizophrenia	Major Depressive Disorder, Schizophrenia

invega sustenna rexulti

Rating

70/100

New

Pharmacy pays

—

Type

Active ingredient

PALIPERIDONE PALMITATE

BREXPIPRAZOLE

Manufacturer

Janssen Pharms

Otsuka

Dosage forms

Injectable

Tablet, Kit

Drug class

Atypical Antipsychotic

Boxed warning

Treats

Bipolar Disorder, Depressive Disorder, Schizophrenia

Major Depressive Disorder, Schizophrenia

Frequently asked questions

What is the difference between Invega Sustenna and Rexulti?

Invega Sustenna contains Paliperidone Palmitate, while Rexulti contains Brexpiprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.